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FIGURE 2 5 Copper’s roles in the Mitochondria and in protein misfolding Copper is a highly reactive metal, but it is an essential cofactor for several vital enzymes, notably two that are active in the mitochondria

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Pro-Oxidant Function of Selenium In humans, according to World Health Organization (WHO) standards, the recommended dose of Se for adults is 55 μg/day, while the maximum tolerable adult intake without side effects is set at 400 μg/day [273]