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mRNA expression of inflammation, tissue repair and oxidative stress pathways and modulation by NAC We demonstrate evidence of modulation of mRNA expression of inflammation, oxidative stress, tissue repair and antioxidant genes with and without NAC (Figures 5a, the mRNA expression was significantly higher in tobacco-exposed MI rats compared to tobacco-naïve MI rats for IL-6 ( P =0.001) and TNF- α ( P =0.001), IFN- γ ( P =0.001) and p22 phox ( P =0.001))