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The different CRP isoforms, nCRP, non-native pentameric CRP (nnCRP) and mCRP (175–178, 181–184), may explain their protective and destructive effects, with nCRP being primarily antiinflammatory inducing Th2/M2 responses, while mCRP being typically proinflammatory inducing Th1/M1 responses (170, 185–189)