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Ipamorelin acts on a separate receptor (GHSR rather than GHRHR), which is why researchers studying the GH axis frequently administer a GHRH analog and a ghrelin mimetic together — see the CJC-1295 + Ipamorelin blend for a combined-compound research format

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It has been the subject of published research into melanocortin receptor pharmacology, particularly at the MC1R (melanogenesis-associated) and MC4R receptors

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