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ROS including superoxide (O 2 – ), hydroxyl radical (HO • ), and hydrogen peroxide (H 2 O 2 ) may cause lipid peroxidation, cell membrane damage, inflammation, and autoimmune diseases (Figure 1)

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Once absorbed, it converts enzymatically, first to retinaldehyde, then to retinoic acid, which binds nuclear retinoic acid receptors (RARs) and drives cell-level changes