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To minimize the impact of nonspecific stress stimuli on the experimental animals, they should be handled for 1–2 min daily before the experiment

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Many growth factors such as transforming growth factor (TGF)-β,2 platelet-derived growth factor (PDGF),3 epidermal growth factor (EGF),4 and fibroblast growth factor (FGF),5 as well as interleukin (IL)-16 and tumor necrosis factor (TNF),7 have been evaluated in a wide spectrum of in vivo and in vitro experiments to observe their effects on different elements included in the healing process

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