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Several studies rely on small cohorts that do not stratify participants by folate level or MTHFR genotype and employ disparate methods to quantify DNA methylation (for example, global, LINE-1 or locus-specific promoter assays) (177-182)

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Some of the first symptoms of a metabolic crisis are: extreme sleepiness behavior changes irritable mood poor appetite Other symptoms then follow: fever nausea diarrhea vomiting hypoglycemia If a metabolic crisis is not treated, a child with CTD can develop: breathing problems swelling of the brain seizuresThese are also called "convulsions" or "fits." During a seizure, a person loses consciousness and control of his or her muscles