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Astrocytes become frenemies to neurons when stress levels exceed the threshold Astrocytes take place in antioxidative defense in the CNS, but when oxidative stress surpasses their regulatory capacity, they undergo pathological changes that exacerbate neuronal damage (Fig

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3 Immunohistochemistry of interleukin-1β (IL-1β) in the dorsal root ganglion (DRG) and spinal cord (SC) at (A) 5 min (representative value of phase 1) and (B) 35 min (representative value of phase 2) Graph (bottom) represents the number of immunostained cells in the DRG and SC (mean ± SD)