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(6) Inadequate levels of B12 can disrupt this cycle and lead to the accumulation of homocysteine, which is toxic to neurons and poses an increased risk factor for cardiovascular disease, stroke, and cognitive decline

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All cell lines were regularly tested for mycoplasma contamination using MycoAlert™ Mycoplasma Detection Kit (Lonza) and by assessment of (lack of) DAPI-positive microvesicles under fluorescence microscope