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[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Kumar H, Mishra G, Sharma AK, Gothwal A, Kesharwani P, Gupta U

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Five Peptides Every Endurance Athlete Should Understand—From Mitochondrial Signaling to Connective-Tissue Remodeling—and How AI Helps By Tony Medrano | CEO & Co-Founder | LongevityPlan.AI | March 2026 Introduction: Why Peptides Are the New Frontier for Endurance Athletes In the spring of 2015, a small laboratory at the USC Leonard Davis School of Gerontology announced something that made exercise physiologists sit up straight: a sixteen-amino-acid molecule encoded not in our familiar nuclear DNA but in our mitochondrial genome could, when injected into obese mice, replicate many metabolic benefits of exercise—suppressing weight gain, reversing insulin resistance, and boosting endurance.1 The molecule was called MOTS-c, and its discoverers—Changhan David Lee and Pinchas Cohen—had effectively opened a door that the endurance community has been walking through ever since