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CKD is caused by many heterogeneous diseases that are mediated through different pathways, and CKD induces irreversible changes and persistent damage to renal function and structure within months or years

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In a phase 2 clinical trial, retatrutide reduced HbA1c to −2.02%, compared to −1.41% for dulaglutide 1.5 mg and −0.01% for placebo (Table 1)