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135,191,192 While this seminal work focused mostly on DNA recognition and the mechanism of transcriptional regulation, these authors noted the presence of a potential metal binding motif, later shown to be critical for imparting metal selectivity ( vide infra )
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Depletion of GSH or inactivation of GPX4 leads to LOOH accumulation, resulting in the buildup of toxic peroxidation products, consequent membrane damage, and cell death (29)