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Involvement of Oxidative Stress, Inflammation, and Glutamate in Ototoxicity, and their Attenuation by Simultaneous Activation of Nrf2 and Elevation of Antioxidant Compounds

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The lipopoli-saccharides of these Gram-negative bacteria causes endotoxemia in HCV and HBV patients [300], with the consequent decline in SOD and MDA levels [301] and increase in pro-inflammatory cytokines and ROS [302]