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Additionally, recent findings have identified GTP cyclohydrolase-1 (GCH1), dihydroorotate dehydrogenase (DHODH), and several other factors as ferroptosis regulators, further expanding the ferroptosis network and offering new directions for elucidating ferroptosis in OA (48–50)

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However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12—particularly from supplements or injections—may be associated with certain health concerns, though these are correlations rather than proven causal relationships