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Because AOD 9604 does not bind the growth hormone receptor, it does not trigger the IGF-1 cascade
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NNMT is overexpressed in several cancer types, and one study found that inhibiting it with 5-amino-1MQ significantly slowed the proliferation of HeLa cervical cancer cells, triggering cell shrinkage and apoptotic changes in a concentration-dependent manner a finding some researchers view as a potential anti-cancer application
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