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Unlike testosterone-based approaches, PT-141 acts centrally on melanocortin receptors (MC3R, MC4R) in the brain, influencing desire through dopaminergic pathways rather than peripheral blood flow

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Tirzepatide is a synthetic 39-amino-acid peptide that is a dual agonist at the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor