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Harthoorn and his team went on to explore etorphine's use in combination with tranquilizers and sedatives, mitigating the initial excitement that often resulted from the opioids and enhancing recovery from anesthesia by providing a tranquilized plane into which the animal was raised when the etorphine was antagonized

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Moreover, they have been reported to promote cartilage regeneration in OA and play a role in harmful processes such as osteophyte formation and inflammation, which further exacerbate cartilage degradation (Fig