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This was evidenced by in vivo studies, which revealed a markedly reduced expression of PGC-1α and its target genes in the striatum and muscle of HD mice ( A number of in vivo studies have demonstrated that mHtt is involved in the process of mitophagy or regulates intermediately important aspects in animal models of HD

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This highlights the resolved “corneal angiogenic privilege”, a corneal avascular state known to be essential for cornea healing and transparency maintenance [122,123,124,125,126,127,128]