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However, the same group reported the formation of both N 2 -hm-dG (most of the tissues) and N 6 -hm-dA monoadducts (only in bone marrow) in rats that were dosed by gavage with 13 C-labeled methanol, which is a precursor of formaldehyde (Lu et al., 2012b)

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Out of 31 compounds only three displayed considerable inhibition of GR and TrxR, thus demonstrating a highly selective behavior for most analogues towards TGR and the related important host enzymes