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In a recent follow-up study using a model of folate deficiency, this group also showed that PQQ treatment (10 days, 20 mg/kg/day) reversed the effects of folate deficiency in brain tissue (inflammation, oxidative stress, and mitochondrial dysfunction) and increased expression of RFC, suggesting PQQ may improve folate uptake and reverse neurodevelopmental abnormalities that arise with brain folate deficiency [91]

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