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This transgenic mouse overexpresses the human amyloid precursor protein (APP) carrying two familial AD mutations: The Swedish mutation (KM670/671NL), which increases total Aβ production by enhancing β-secretase cleavage, and the Indiana mutation (V717F), which alters γ-secretase cleavage to favor production of the more aggregation-prone amyloid-beta 1–42 peptide (Aβ 1–42 ) [464–467]

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