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For individuals with advanced disease and persistent symptoms refractory to conservative treatment, joint replacement surgery is a viable option (Anandacoomarasamy and March, 2010)

Adenosine

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Tesamorelin + Ipamorelin Side Effects & Safety Compound-level safety From tesamorelin trials, the most commonly reported adverse events include injection-site reactions (redness, itching), joint pain (arthralgia), pain in the extremities, peripheral edema (fluid retention), and muscle aches