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It is unclear why the R-domain mutants showed a higher loss of activity, but it is possible there are other compensating interactions between the phosphorylated R-domain and the overall positive charge of NBD1

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30,32 A retrospective matched case-control study of 324 patients who underwent ACL reconstruction with meniscus repair (PRP vs control age: 91.6 ± 11.2 vs 92.4 ± 10.6) showed no significant difference in IKDC scores nor in the timing of return to activity nor postoperative complications among the intraoperative PRP injection group and the control group after 2 years 33 In addition, Bailey et al

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