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Additionally, BBR downregulates miR-34a, miR-34b-5p, and miR-470-5p in the mouse hippocampus, while significantly upregulating brain-derived neurotrophic factor (BDNF), synaptotagmin-1, and Bcl-2, improving dendritic spine morphology and promoting hippocampal neuron growth to relieve depressive symptoms (Yi et al., 2020[249]
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Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice
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