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Calculation of ICC and Heritability For twin studies the one-way model of intra-class correlation (ICC) is used to determine the similarity of a measure in a twin pair, ICC = (MS between − MS within ) / (MS between + MS within ), where MS between is the estimate of the mean-square variance between all twin-pairs and MS within is the estimate of the mean-square variance within the sets of pairs in that group [23]

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