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The MTHFD1 encoded enzyme possesses three activities that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase

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The mechanisms underlying the association between adolescent cannabis use and risk of psychotic and cognitive symptoms later in life have been explored in various animal models using exposure to escalating doses of Δ-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis