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Subsequent sex comparison analysis showed that compared to that in healthy men, healthy women had higher GSTA4 methylation levels CpG1 ( p = .004, Table 5), CpG2 ( p = .024), CpG3 ( p = .042), CpG4 ( p = .041), CpG6 ( p = .038), CpG8 ( p = .035), CpG9 ( p = .02), mean methylation levels of the nine CpG sites ( p = .019)

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SIZE:35ml

Furthermore, homocysteine may also disrupt the hypothalamic-pituitary-gonadal axis by interfering with the release of GnRH and luteinizing hormone, which are crucial for stimulating testosterone production [74]