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first reported the dedifferentiation of hepatocytes into fibroblasts via EMT ( Snail and Slug , repressing the mesenchymal program and EMT of hepatocytes ( Hepatocytes could also dedifferentiate into hepatic progenitor cells (HPCs, which are identified by markers such as SMA, SOX9, KRT19, EpCAM, and PROM1), and the proliferation and differentiation of hepatocyte-derived HPCs are closely associated with ductular reactions and portal fibrosis in liver injury ( Mat1a - / - mice transformed into fibroblastic cells when incubated with FGF10 and TGF-β1, and these HPC-derived fibroblasts were significantly expanded in RRV-induced BA mouse model ( 9
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Such infiltrates were even found in the areas, where its structure was not significantly altered
